Don’t fill this out if you’re human:
Thank you for submitting your results to our open-source database for in vivo brain MRS. Your contribution is helping researchers and clinicians advance our field, create a stronger community, and helping standardize resources. Once you've completed your submission, please wait 2-3days for your submission to be available in the database.
There are 6 sections we need information for your submission. Please include as much information as possible, but know that some sections may be irrelevant for your experiment. If you're unsure where to find any of this information, the Reproducibility Made Easy (REMY; Link) free software, actively under development, automatically finds and creates a table with acquisition and methods parameters.
Please note, we are currently only accepting peer-reviewed published results. This will likely change as we continue to build our database.
If you would like to get involved, please reach out to Aaron Gudmundson, PhD (aarongudmundsonphd@gmail.com)
Gudmundson, A. T., Koo, A., Virovka, A., Amirault, A. L., Soo, M., Cho, J. H., Oeltzschner G., Edden R. A. E., & Stark, C. E. (2023). Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease. Analytical biochemistry, 676, 115227. Link
Your First Name:*
Your Middle Initial(s):
Your Last Name:*
Your Email Address:*
Author's First Name:*
Author's Middle Initial(s):
Author's Last Name:*
Publication Title:*
Publication Year:*
Journal Volume:
Digital Object Identifier (DOI):*
How many Healthy/Control Groups:
How many Clinical Groups:
How many protocols:
How many brain regions:
How many timepoints/sessions:
How many treatments/shams:
Other Conditions:
Note* If you know that this does not reflect the correct number of rows, please simply refresh the page and enter the correct number in the healthy/control group section and leave all the region, protocol, treatment, etc. set to 1.
helpGroup Label:Add a unique group name. Default is Group 1.. Group 2.. Group 3.. etc. Group Label
helpPopulation:The population associated with this group (e.g., Healthy, Bipolar Disorder, Type 2 Diabetes, Parkinson's Disease, Alzheimer's Disease, etc.) Population
helpDoes this Group have a Control:The Group Label or Number of the Control Group for the Current Group. If this group does not have a control group, please leave blank. Does this Group have a Control:
helpNumber of Female Subjects:This is the total number of female subjects Number of Female Subjects:
helpNumber of Male Subjects:This is the total number of male subjects Number of Male Subjects:
helpTotal Number of Subjects:This is the total number of subjects in the group Total Number of Subjects:
helpAge Mean of Subjects (Years):This is the mean age of the group in years Age Mean of Subjects (Years):
helpAge Std. Dev. of Subjects (Years):This is the standard deviation of the age for the group in years Age Std. Dev. of Subjects (Years):
helpField Strength (Tesla):The field strength of the scanner (e.g., 1.5 Tesla or 3.0 Tesla) Field Strength (T):
helpScanner Manufacturer:The manufacturer or vendor of the scanner (e.g., Siemens, Philips, GE, etc.) Scanner Manufacturer:
helpScanner Model:The model name for the scanner (e.g., PRISMA, Achieva, Optima, etc.) Scanner Model:
helpWater Suppression:The method of water suppression used during the acquisition (e.g., CHESS, VAPOR, etc.) Water Suppression Method:
helpLipid Suppression:The method of lipid suppression used during the acquisition Lipid Suppression Method:
helpLocalization:The Localization method (e.g., PRESS, STEAM, ISIS, LASER, sLASER, etc.) Localization:
helpMulti-Scan (e.g., MEGA)If multiple experiments are performed to complete the acquisition (e.g., MEGA) Multi-Scan (e.g., MEGA):
helpWater Reference Collected:Whether a non-water-suppressed scan was acquired to be used as a reference. (Yes/No) Water Reference Collected:
helpSpectral Width (Hz):The spectral width of the data acquisition in Hertz. This is equivalent the inverse of the dwell time, or sampling rate Spectral Width (Hz):
helpNumber of Datapoints:The number of datapoints collected in time-domain signal (e.g., 1024, 2048, 4096, etc.) Number of Datapoints:
helpNumber of Transients/Averages:The number of transients collected (somtimes referred to as averages). Number of Transients/Averages:
helpRepetition TimeThe repetition time (TR) or time between each transients. Repetition Time (s):
helpEcho Time (s)The echo time (TE) or amount of time between the excitation pulse and start of the acquisition. If a TE-series was used, please separate each value with a comma (TE1, TE2, TE3, etc.) Echo Time (s):
helpInversion Time (s)The inversion time (TI) or amount of time between an inversion pulse and the excitation pulse. Please separate each value with a comma (TI1, TI2, TI3, etc.) Inversion Time (s):
helpBrain RegionThe brain region where the voxel was placed (e.g., Occipital, Parietal, medial Prefrontal, etc.) Brain Region:
helpHemisphere (Left/Right/Both)Hemisphere where data was collected. If voxel was located in center, please select 'Both' Hemisphere (Left/Right/Both):
helpPrimary Tissue TypeThe primary tissue type of the voxel (e.g., Gray matter, White Matter, or Mixed). If a tissue type did not occupy greater than or equal to 65%, then the voxel is 'Mixed.' Primary Tissue Type:
helpGray Matter Percent:The percent of Gray Matter present in the voxel. Gray Matter Percent:
helpGray Matter Std. Dev.:The standard deviation of Gray Matter as a percentage that is present in the voxel. Gray Matter Std. Dev.:
helpWhite Matter Percent:The percent of White Matter present in the voxel. White Matter Percent:
helpWhite Matter Std. Dev.:The standard deviation of White Matter as a percentage that is present in the voxel. White Matter Std. Dev.:
helpCSF Percent:The percent of CSF that is present in the voxel. CSF Percent:
helpCSF Std. Dev.:The standard deviation of CSF as a percentage that is present in the voxel. CSF Std. Dev.:
helpVoxel Dimension 1 (mm):The size of the voxel in the 1st dimension in units of mm Voxel Dimension 1 (mm):
helpVoxel Dimension 2 (mm):The size of the voxel in the 2nd dimension in units of mm Voxel Dimension 2 (mm):
helpVoxel Dimension 3 (mm):The size of the voxel in the 3rd dimension in units of mm Voxel Dimension 3 (mm):
helpIs this Metabolite Nulled/Cycled:Select metabolite-nulled, metabolite-cycled, or leave blank. Is this Metabolite Nulled/Cycled:
helpSegmenetation Software:The software used to perform brain segmentation (e.g., SPM, Freesurfer, ANTS, etc.). Please put 'in-house' if a custom unpublished segmentation tool was used. Segmentation Software:
helpFitting Software:The software used to fit, or model, the data (e.g., LCModel, Tarquin, Osprey, JMRUI, Inspector, etc.). Please put 'in-house' if a custom unpublished fitting tool was used. Fitting Software:
helpPartial Voluming Performed:Yes/No - Results were corrected for partial voluming, or differing tissue compositions within participants. Partial Voluming Performed:
helpRelaxation Correction Performed:Yes/No - Results were corrected for effects of T1 and T2 Relaxation Correction Performed
Now that we've filled in all of the publication, study, and methods information, we will move onto the metabolite values. There are 5 items to choose from below: Referenced to Total Creatine (tCr), Institutional Units (IU), millimolar (mM), T1, and T2. Please select each that you are submitting data for. A new section will appear for each of the options selected.
helptCrResults are a concentration type that are referenced to total creatine. Referenced to total Creatine (tCr)
helpIUResults are a concentration type that are given in institutional units. Institutional Units (IU)
helpmM:Results are a concentration type that are given in millimolar. millimolar (mM)
helpT1:Results are a Relaxation type that are given in milliseconds. T1 (ms)
helpT2:Results are a Relaxation type that are given in milliseconds. T2 (ms)
A few notes:
The columns are still ordered according to the group information you entered above. The Group Label is simply there for convenience - please do not change the group labels.
Also, you will likely not have values for all of the metabolites listed below. This list is meant to be comprehensive and all-inclusive for various nuclei (e.g., 1H, 31P, 13C, etc.) and acquisitions.
Group Label
Acetate (Ace)
Adenosine Triphosphate (ATP)
Alanine (Ala)
Ascorbate (asc)
Aspartate (asp)
β-hydroxy-butyrate (2HB)
β-hydroxy-glutarate (2HG)
Citrate (Cit)
Cysteine (Cys)
Creatine (Cr)
Ethanolamine (ETA)
Ethyl Alcohol (EtOH)
γ-butyric acid (GABA)
Glucose (Glc)
Glutamine (Gln)
Glutamate (Glu)
Glutamate + Glutamine (Glx)
Glutathione (GSH)
Glycerophosphocholine (GPC)
Glycine (Glyn)
Glycerol (Glyc)
Histamine (Hist)
Homocarnosine (HCr)
Macromolecule 0.93ppm (MM0.93)
Macromolecule 1.21ppm (MM1.21)
Macromolecule 1.39ppm (MM1.39)
Macromolecule 1.67ppm (MM1.67)
Macromolecule 2.04ppm (MM2.04)
Macromolecule 2.26ppm (MM2.26)
Macromolecule 2.56ppm (MM2.56)
Macromolecule 2.70ppm (MM2.70)
Macromolecule 2.99ppm (MM2.99)
Macromolecule 3.21ppm (MM3.21)
Macromolecule 3.62ppm (MM3.62)
Macromolecule 3.75ppm (MM3.75)
Macromolecule 4.03ppm (MM4.03)
myo-Inositol (mI)
N-acetyle-aspartate (NAA)
N-acetyle-aspartyl-glutamate (NAAG)
Phosphocholine (PCho)
Phosphocreatine (PCr)
Phosphoethanolamine (PhE)
Phenylalanine (Phy)
scyllo-Inositol (sI)
Serine (Ser)
Taurine (Tau)
Threonine (Thr)
Tryptophan (Try)
Tyrosine (Tyr)
Valine (Val)
Thank you again for your contribution to our MRS Database!
Take a final moment to add any final notes. Notes might include unique features or additional information not available in the publication.